https://doi.org/10.15255/KUI.2021.062
Published: Kem. Ind. 71 (5-6) (2022) 287–293
Paper reference number: KUI-62/2021
Paper type: Original scientific paper
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Hemi-synthesis of Thione and Thiol Derivatives from Artemisia judaica L. Essential Oil, and Antimicrobial Tests

A. Drioueche, H. Boutoumi, N. Benmansour and H. Lettreuch

Abstract

The applications of organosulfur compounds, especially thioketones are varied which concerns both synthetic and biological chemistry. In this context, from the essential oil of Artemisia judaica L., extracted by hydrodistillation, and consisting mainly of piperitone (91.77 %), thione, and thiol derivatives were hemi-synthesized via a thionylation reaction byphosphorus pentasulphide (P₂S₅). The possible thione-thiol tautomerism in solution followed spectrophotometrically revealed the predominance of thiol form in solution. The antimicrobial activity of essential oils showed that the thionylation of essential oil caused a considerable increase in antimicrobial activity in particular against Escherichia coli.

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Keywords

Artemisia judaica L., essential oil, thionylation, tautomerism, antimicrobial activity