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Published: Kem. Ind. 70 (7-8) (2021) 369–374
Paper reference number: KUI-62/2020
Paper type: Original scientific paper
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Preventive Activity of Giner (Zingiber officinale) Against Myelotoxicity and Hepatotoxicity Induced by Cyclohexatriene and Identification of the Most Active Compounds by GC-MS

K. Otmanine, S. Hanini, O. Benkortbi, R. Bekri, K. Amroun, M. Djellal, S. Kohli and K. Benachour


This study aimed to uncover the preventive capability of Zingiber officinale against myelotoxicity, leukaemia, and hepatotoxicity. For the most part, this work depended on the subcutaneous injection of cyclohexatriene in rabbits to cause the illness by a synthetic strategy. In parallel, another group of rabbits was exposed to the injection of cyclohexatriene under similar conditions with the feeding Zingiber officinale, where it was discovered that the cyclohexatriene-induced myelotoxicity was counteracted. The histological examination additionally uncovered the hepato-defensive intensity of Zingiber officinale. The most pharmacologically active molecules of Zingiber officinale were recognised by gas chromatography–mass spectrometry (GC-MS).

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Zingiber officinale, hepato-protective activity, cyclohexatriene, myelotoxicity, GC-MS