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https://doi.org/10.15255/KUI.2019.032
Published: Kem. Ind. 68 (9-10) (2019) 389–396
Paper reference number: KUI-32/2019
Paper type: Original scientific paper
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3D-Printed Oral Dosage Forms Loaded with Dispersion of Oil and Active Ingredient

A. Milićević, M. Gretić and G. Matijašić

Abstract

In this study, the possibility of producing pharmaceutical dosage forms by 3D printing technology is examined. In vitro dissolution tests were performed with printed dosage forms, and the results analysed in Microsoft Excel Add-In, DDSolver. 3D printing has provided six different models of solid dosage forms. The results of dissolution test have shown release profiles with initial time delay. The profiles are described by the Peppas-Sahlin model. It is shown that 3D printing technology has the potential to become a method for quick and simple production of personalized dosage forms with delayed release.


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Keywords

3D print, personalized medicines, delayed release, release profiles, Peppas-Sahlin model