https://doi.org/10.15255/KUI.2019.007
Published: Kem. Ind. 68 (9-10) (2019) 375–380
Paper reference number: KUI-07/2019
Paper type: Original scientific paper
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Electrospun Polycaprolactone for Controlled Drug Delivery

E. Govorčin Bajsić, E. Zdraveva, B. Mijović, T. Holjevac Grgurić, M. Tominac Trcin and T. Zubin Ferri

Abstract

Tissue engineering is a good alternative for the development of tissue or potential organs from the patient’s own cell material in order to reduce the problem of organ transplant deficiency. Electrospun materials are good candidates for use in biomedicine, as scaffolds for tissue cells culture. Additionally, these scaffolds can provide controlled drug release in tissue regenerative therapies. In this paper, controlled release of antibiotic Cefuroxim (CFU), which is used for ocular tissue therapy, was investigated. The polycaprolactone scaffolds were prepared by electrospinning with the addition of CFU in the amount of 1, 2, 5, and 10 wt %. The successful antibiotic capsulation was confirmed by the new characteristic peaks appearing in the FTIR spectra of the electrospun blends. With the addition of antibiotic and increase in its concentration, fibres with more uniform morphology and less deformations along the fibres length were obtained. The release of antibiotic from PCL scaffolds was determined by UV–VIS spectrophotometer. Obtained was an increase in absorption of antibiotics with time and with increased drug concentration in the scaffolds.

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Keywords

electrospinning, polycaprolactone, Cefuroxime, scaffolds, tissue engineering