https://doi.org/10.15255/KUI.2015.051
Published: Kem. Ind. 66 (1-2) (2017) 17–28
Paper reference number: KUI-51/2015
Paper type: Review
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3-Hydroxypyridin-4-ones (Part II): Biological Application as Iron Chelating Agents

Ž. Car, V. Petrović Peroković and S. Tomić Pisarović

Abstract

Selectivity towards trivalent metal cations, especially Fe(III), is the primary basis of a number of 3-hydroxypyridin-4-ones’ biological activities. These compounds have high potential in the treatment of iron overload diseases, in various blood pathologies such as thalassemia and hemochromatosis, as well as in the treatment of neurodegenerative diseases, such as Alzheimer’s disease. Beside deferiprone, the only 3-hydroxypyridin-4-one based iron(III) chelating agent which has been used clinically for more than 30 years, this review will also present other most significant and potentially biologically active chelators with 3-hydroxypyridin-4-one core.

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Keywords

3-hydroxypyridin-4-ones, iron(III), chelation based therapeutics, deferiprone, thalassemia, Alzheimer's disease