https://doi.org/10.15255/KUI.2014.020
Published: Kem. Ind. 64 (9-10) (2015) 481−498
Paper reference number: KUI-20/2014
Paper type: Review
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1,3-Dipolar Cycloaddition (Part I): Synthesis of 1,2,3-Triazole Derivatives in Nucleoside Chemistry

D. Saftić, L. Krstulović, M. Bajić and B. Žinić

Abstract

Copper catalysed Huisgen 1,3-dipolar cycloaddition of azides and alkynes which leads to 1,4-disubstituted-1,2,3-triazoles is a frequently used method in synthetic organic chemistry. Due to the simple reaction conditions, it has occupied an important place in the field of nucleoside chemistry since it enables preparation of a large number of potentially biologically active compounds with a number of interesting additional properties induced by the presence of 1,2,3-triazole structural motif in the molecule.

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Keywords

click chemistry, nucleosides, 1,2,3-triazole nucleoside analogs