https://doi.org/10.15255/KUI.2011.028
Published: Kem. Ind. 60 (12) (2011) 639–646
Paper reference number: KUI-28/2011
Paper type: Review / Applying Research Results to Production
Download paper:  PDF

Chemistry in the Galapagos Research Center Ltd., Zagreb

V. Gabelica Marković, M. Mesić, S. Alihodžić and K. Kovačević

Abstract

Galapagos Research Centre d. o. o., is a private research organization, active in the field of chemistry, biology, biomedicine, veterinary science and pharmacy. This article is devoted to the International Year of Chemistry; this review includes the areas of study undertaken by the chemists in the research centre. Also presented are the current techniques and technologies applied in the implementation of research and development projects. The main activities of chemists are directed to the synthesis of new organic compounds resulting in potentially new medicines, their subsequent identification, structural characterization, purification process, magnification (scale up), the applied analysis of biological materials (DMPK – Drug Metabolism and Pharmacokinetics) and the pharmaceutical development of preclinical candidates. Project teams at Galapagos incorporate researchers of all relevant professions to explore the potential of new medicines. These include chemists (chemical engineers and technologists), biologists, medical doctors, veterinarians and pharmacists. The ultimate goal of each of the projects is to establish an effective, well-defined preclinical candidate, which is further developed in other parts of the organization (Belgium, France, Great Britain), otherwise in the development laboratories of large partner organizations. This research article includes research and technology supported by concrete examples, and the results published in previous articles.

This work is licensed under a Creative Commons Attribution 4.0 International License

Keywords

Galapagos Research Centre Zagreb, medicinal chemistry, drug discovery, physical & chemical characterization, scale-up synthesis