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Published: Kem. Ind. 61 (2) (2012) 71–120
Paper reference number: KUI-04/2011
Paper type: Review
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III. Organometallic and Bioorganometallic Chemistry – Ferrocene Peptides

V. Rapić+ and M. Kovačević


This paper is devoted to the bioconjugates of ferrocene with naturally occuring amino acids/peptides – mostly dealing with authors' results accompanied, to a lesser degree, by the relevant literature data. Chapter 2 deals with natural peptides and peptidomimetics, mainly focusing on α-helix and β pleated sheet (as the most important elements of peptide secondary and tertiary structure), and artificial β-sheets nucleated by non-amino acid turn inducers. Chapter 3 describes peptides generated from ferrocenecarboxylic acid and ferroceneamine, as well as with the bioconjugates of heteroannulary substituted ferrocene-1,1'-dicarboxylic acid (Fcd) and ferrocene-1,1'-diamine (Fcda). Chapter 4 elaborates authors' papers about peptides based on 1'-aminoferrocene-1-carboxylic acid (Fca). Chapter 5 is devoted to the new monosubstituted Fcd and Fcda conjugates with amino acids, while Chapter 6 describes our publications in the field of very topical peptidomimetics – ferrocene ureidopeptides and β-peptides. Conformational analysis of the newly prepared ferrocene bioconjugates in solution and solid state was performed by means of spectroscopic methods (CD, IR, 1D- NMR, 2D-NMR, v. r. NMR, and temperature and concentration dependent NMR) and DFT calculations.

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bioorganometallic chemistry, ferrocene peptides, preparations, reactions, structure