https://doi.org/10.15255/KUI.2023.037
Published: Kem. Ind. 73 (5-6) (2024) 215–220
Paper reference number: KUI-37/2023
Paper type: Original scientific paper
Download paper:  PDF

Correlation between Optical Characteristics of Orodispersible Films with Selected Process Parameters Supported by FTIR Analysis

O. Rahić, A. Tucak-Smajić, M. Šahinović, B. Imamović, L. Hindija, J. Hadžiabdić and E. Vranić

Abstract

Paediatric and geriatric populations, as well as other special patient populations with swallowing problems, require patient-tailored dosage forms. One promising dosage form for these specific populations is orodispersible films. When preparing orodispersible films using sodium carboxymethyl cellulose as the film-forming polymer and glycerine as the plasticizer, it is essential to determine the optimal mixing time and mixing speed of the casting solution to achieve the desired transparency/opacity of the orodispersible films. In this paper, the primary focus is on mixing time and mixing speed, and determining how these two parameters can influence optical characteristics. All tested parameters are supported by FTIR analysis. The obtained results show that either a mixing speed of 7000 rpm on a high-shear mixer for 15 min or a mixing speed of 9000 rpm for 5 min can produce films with optimal optical characteristics.

This work is licensed under a Creative Commons Attribution 4.0 International License

Keywords

orodisperisble films, sodium carboxymethyl cellulose, glycerine, optical characteristics, FTIR