https://doi.org/10.15255/KUI.2023.014
Published: Kem. Ind. 72 (11-12) (2023) 679–691
Paper reference number: KUI-14/2023
Paper type: Review
Download paper:  PDF

Dragutin Fleš – Founder of Organic Stereochemistry in Croatia

V. Šunjić

Abstract

The presentation of stereochemical research of chiral organic molecules and optically active polymers reveals Academician Dragutin Fleš as the founder of this field of organic stereochemistry in Croatia. Here are presented the most important scientific achievements in the synthesis of chiral β-amino acids and their analogues, and correlation of absolute configuration in some biologically important compounds, such as ephedrine and chloramphenicol. The presentation follows a chronological sequence, exploringresearch in the field of optically active polymers prepared from chiral derivatives of cysteine through reactive β-thiolactones, as well as from mono- and di-substituted butadienes and vinyl-alkyl ethers.

This work is licensed under a Creative Commons Attribution 4.0 International License

Keywords

chiral organic molecules, correlations of absolute configuration, optically active polymers