https://doi.org/10.15255/KUI.2023.005
Published: Kem. Ind. 72 (7-8) (2023) 455–462
Paper reference number: KUI-05/2023
Paper type: Original scientific paper
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Ru(III) Complexes and Their Ligands Derived from Salicylaldehyde and Halogenated Anilines: Synthesis, Characterisation, and Antioxidant Activity

N. Ljubijankić, E. Šuta, A. Ćatić, S. Begić, S. Ljubijankić and S. Ibragić

Abstract

This work aimed to describe the synthesis and characterisation of two anionic Ru(III) complexes of the general formula Na[RuCl₂(N-4-Cl-Ph-salim)₂] and Na[RuCl₂(N-3-Br-Ph-salim)₂, their associated ligands, and determine their antioxidant activity. The ligands N-4-Cl-phenylsalicylidenimine (N-4-Cl-Ph-salimH, HL^a) and N-3-Br-phenylsalicylidenimine (N-3-Br-Ph-salimH, HL^b), Schiff bases, were synthesised from salicylaldehyde and chloroaniline or bromoaniline. The compounds were characterised using IR spectroscopy and ESI ToF mass spectrometry. The following was confirmed: coordination of ligands on the Ru(III) centre, the molecular formulas, and the corresponding M^– ions: [C₂₆H₁₈N₂O₂Cl₄Ru]^–26H₁₈N₂O₂Cl₂Br₂Ru]^– ion, (m/z: 719.8283). The antioxidant activity was determined by the ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. In contrast to the ligands, both complexes proved to be strong scavengers of the ABTS and DPPH radicals with IC₅₀ (half maximal inhibitory concentration) values comparable to those of Trolox. As such, they present valuable candidates for further research related to their biological properties.

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Keywords

Ru(III) complexes, Schiff bases, IR spectroscopy, ESI ToF mass spectrometry, antioxidant activity