Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System

T. . Nguyen, T. Hong-Ngan Tran, C. Nguyen, C. Im and C. Dang

Abstract
The aim of this work was to study a novel nanoparticle system formed from alginate and β-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca2+/alginate gel and β-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), Fourier transform infrared spectra (FTIR). The nanoparticle size was about 50 – 80 nm and their structure quite regular and consistent. Ketoprofen, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 50.7 % and loading efficiency of 5.7 %. Ketoprofen released from the nanoparticles was 57 % at pH 7.4 and 69 % at pH 5.0 for 4 h.

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Keywords
nanoparticle, nanocarrier, drug delivery, β-cyclodextrin, alginate, ketoprofen, drug release