Solubility of Thiamine in Pure and Mixed Solvents in Function of Temperature

L. C. P. Borges, A. H. R. Rezende, A. C. Granato and R. F. Pires

Abstract
The present paper details the solid-liquid equilibrium (SLE) of thiamine in pure dimethylsulfoxide (DMSO) and aqueous solvent mixtures of varying DMSO concentrations. The solubilities were measured in the temperature range of 298.15 K to 323.15 K at 5.0 K intervals, under atmospheric pressure, by employing gravimetric analysis. The experimental results indicate that the vitamin’s solubility increases with increasing temperature and the water mass present in the initial solvent mixture. The adjustments using rational models were satisfactory, achieving adequate correlations and predicting the values of the solubility measurements in the laboratory with acceptable accuracy

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Keywords
solid-liquid equilibrium, thiamine, vitamin, solvent, rational models, solubility