Evaluation and Modeling of the Aerobic Stirred Bioreactor Performances for Fungus Broths

A. Galaction, D. Cașcaval, C. Oniscu and M. Turnea

Abstract
The mixing time and oxygen mass transfer coefficient represent two of the most important quantities implied on the design and operation of the bioreactors. In this paper, the influences of the main characteristics of bioreactor and of fungus broths (P. chrysogenum, free mycelia and mycelial aggregates) on mixing efficiency and oxygen mass transfer, are studied. By means of the experimental data, some mathematical correlations describing the influences of the considered factors on mixing time and kla, have been proposed. The proposed correlations can be used in bioreactor performance evaluation, optimization, and scaling-up.

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Keywords
stirred bioreactor, mixing time, mass transfer coefficient, Penicillium chrysogenum, Pellets, free mycelia