Specification and Supervision of System Performance in Yeast Bioprocesses

E. Franco-Lara, R. Krull, D. Hempel and A. Haarstrick

Abstract
Three different case studies addressing the specification of systemperform ance and estimation of optimal cultivation policies are examined for different yeast cultivation systems. In the first case, the industrial production of baker’s yeast in bubble columns serves as illustration of primary model conception and exemplifies task-oriented reduction of model complexity. Within this simplified model-supported framework, different optimization techniques, that maximize process productivity, are demonstrated and compared in a second case study, the invertase production with a recombinant Saccharomyces cerevisiae strain. Finally, in the third case, the integration of specific process constrains of physical nature proper of the bioprocess is demonstrated on the optimal production of the protein GAL80 with the yeast Kluyveromyces lactis.

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Keywords
Yeast processes, system performance, model-based optimization, soft-sensor