Novel Micro-scale Analytical Devices for On-line Bioprocess Monitoring: A Review

P. Hrnčiřík and J. Náhlík

Abstract
This review examines the potential of novel micro-scale microfluidic analytical devices – lab-on-a-chip (LOC), micro total analysis systems (μ-TAS) – for on-line monitoring and control of industrial bioprocesses. First, motivation for the current study is presented and potential benefits from the use of micro-scale analytical devices in bioprocess control and monitoring are outlined. This is followed by a review of the state of the art in the relevant application domain (cell analysis) for novel microfluidic analytical devices. Finally, the conclusion provides a summarizing comparison of the main features of the reported micro-scale analytical devices evaluating their potential applicability for on-line bioprocess monitoring, with the most promising concepts identified.

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Keywords
Bioprocess monitoring, lab-on-a-chip, micro total analysis systems, single-cell analysis