Nonsteroidal Anti-Inflammatory Drug Solid-State Microencapsulation on Green Activated Carbon - Mass Transfer and Host-Guest Interactions

Z. L. Yaneva

Abstract
The present study investigated the drug-carrier capacity of green activated carbon derived from fruit stones by steam-gas activation (ACSTA) towards the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen (IBU), and assessed the host-guest interactions and mass transfer mechanism/s of the drug microencapsulation and in vitro release processes. The mass transfer studies outlined that the process of IBU encapsulation on ACSTA microparticles was predominantly controlled by intraparticle solid phase diffusion.

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Keywords
microencapsulation, ibuprofen, activated carbon, in vitro release