Nanoencapsulation of Drug-loaded Lipid by Temperature-induced Phase Transition

H. Lee, J. Y. Kim, E. J. Koo, J. Lee, E. H. Lee, K. S. Oh and S. H. Yuk

Abstract
Pluronic nanoparticles (NPs) were prepared by means of a temperature-induced phase transition in the mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing model drugs such as orlistat, caffeine, and ibuprofen sodium salt. Liquid soybean oil/Tween 80 was used as a solubilizer for model drugs, and Pluronic F-68 was the polymer that stabilizes liquid soybean oil/Tween 80 containing model drugs. Field-emission scanning electron microscopy and particle size analyzer were used to observe the morphology and size distribution of the prepared NPs. X-ray diffractometer was used to understand relationship between the crystalline state of the model drug and its solubility in the aqueous media. To observe the feasibility of Pluronic NPs as a drug delivery system, the release pattern of model drugs was observed.

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Keywords
Nanoencapsulation, pluronic, temperature – induced phase transition, solubility